Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These
proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA …

Zinc-finger proteins, a superfamily of proteins with a typical structural domain that
coordinates a zinc ion and binds nucleic acids, participate in the regulation of growth …

Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders that often progress
to chemotherapy-resistant secondary acute myeloid leukemia (sAML). We used whole …

The helicase RIG-I initiates an antiviral immune response after recognition of pathogenic
RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is …

Toll-like receptors (TLRs) recognize microbial components, and evoke inflammation and
immune responses,,. TLR stimulation activates complex gene expression networks that …

Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the
excessive generation or accumulation of free radicals or their oxidation products. Free …

The intensity and duration of macrophage-mediated inflammatory responses are controlled
by proteins that modulate inflammatory signaling pathways. MCPIP1 (monocyte chemotactic …

Numerous inflammatory cytokines have been implicated in the pathogenesis of
cardiovascular diseases. Monocyte chemoattractant protein (MCP)-1/CCL2 is expressed by …

MicroRNAs (miRNAs) are versatile regulators of gene expression and undergo complex
maturation processes. However, the mechanism (s) stabilizing or reducing these small …

Microglia participate in innate inflammatory responses within the central nervous system.
The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as …