The genus Flavivirus contains more than 70 single-stranded, positive-sense arthropod-
borne RNA viruses. Some flaviviruses are particularly medically important to humans and …

Proteins can bind target molecules through either induced fit or conformational selection
pathways. In the conformational selection model, a protein samples a scarcely populated …

Viruses must gain entry into cells to establish infection. In general, viruses enter either at the
plasma membrane or from intracellular endosomal compartments. Viruses that use …

Reactive cysteines often serve as functional sites on proteins and play important regulatory
roles in various biological processes. A chemoproteomic method named “isoTOP‐ABPP” …

Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We
screened multiple orthologous RNAi reagents and identified host proteins that modulate …

Autophagy is a finely orchestrated process required for the lysosomal degradation of
cytosolic components. The final degradation step is essential for clearing autophagic cargo …

In animal germlines, PIWI proteins and the associated PIWI-interacting RNAs (piRNAs)
protect genome integrity by silencing transposons. Here we report the extensive sequence …

Membrane-bound catechol-O-methyltransferase (MBCOMT), present in the brain and
involved in the main pathway of the catechol neurotransmitter deactivation, is linked to …

Genetic variants in SLC16A11 were recently reported to be associated with type 2 diabetes
in Mexican and other Latin American populations. The diabetes risk haplotype had a …

Type I interferon and apoptosis elicit multifaceted effects on host defense and various
diseases, such as viral infections and cancers. However, the gene/protein network …