Semantic encoding during language comprehension at single-cell resolution

M Jamali, B Grannan, J Cai, AR Khanna, W Muñoz… - Nature, 2024 - nature.com
From sequences of speech sounds, or letters, humans can extract rich and nuanced
meaning through language. This capacity is essential for human communication. Yet …

Home use of a percutaneous wireless intracortical brain-computer interface by individuals with tetraplegia

JD Simeral, T Hosman, J Saab… - IEEE Transactions …, 2021 - ieeexplore.ieee.org
Objective. Individuals with neurological disease or injury such as amyotrophic lateral
sclerosis, spinal cord injury or stroke may become tetraplegic, unable to speak or even …

Accurate estimation of neural population dynamics without spike sorting

EM Trautmann, SD Stavisky, S Lahiri, KC Ames… - Neuron, 2019 - cell.com
A central goal of systems neuroscience is to relate an organism's neural activity to behavior.
Neural population analyses often reduce the data dimensionality to focus on relevant activity …

Making brain–machine interfaces robust to future neural variability

D Sussillo, SD Stavisky, JC Kao, SI Ryu… - Nature …, 2016 - nature.com
A major hurdle to clinical translation of brain–machine interfaces (BMIs) is that current
decoders, which are trained from a small quantity of recent data, become ineffective when …

Single-neuronal predictions of others' beliefs in humans

M Jamali, BL Grannan, E Fedorenko, R Saxe… - Nature, 2021 - nature.com
Human social behaviour crucially depends on our ability to reason about others. This
capacity for theory of mind has a vital role in social cognition because it enables us not only …

Dynamical flexible inference of nonlinear latent factors and structures in neural population activity

H Abbaspourazad, E Erturk, B Pesaran… - Nature Biomedical …, 2024 - nature.com
Modelling the spatiotemporal dynamics in the activity of neural populations while also
enabling their flexible inference is hindered by the complexity and noisiness of neural …

Power-saving design opportunities for wireless intracortical brain–computer interfaces

N Even-Chen, DG Muratore, SD Stavisky… - Nature biomedical …, 2020 - nature.com
The efficacy of wireless intracortical brain–computer interfaces (iBCIs) is limited in part by
the number of recording channels, which is constrained by the power budget of the …

Brain–machine interfaces: Closed-loop control in an adaptive system

E Sorrell, ME Rule, T O'Leary - Annual Review of Control …, 2021 - annualreviews.org
Brain–machine interfaces (BMIs) promise to restore movement and communication in
people with paralysis and ultimately allow the human brain to interact seamlessly with …

Local field potentials reflect cortical population dynamics in a region-specific and frequency-dependent manner

C Gallego-Carracedo, MG Perich, RH Chowdhury… - Elife, 2022 - elifesciences.org
The spiking activity of populations of cortical neurons is well described by the dynamics of a
small number of population-wide covariance patterns, whose activation we refer to as 'latent …

Multiscale low-dimensional motor cortical state dynamics predict naturalistic reach-and-grasp behavior

H Abbaspourazad, M Choudhury, YT Wong… - Nature …, 2021 - nature.com
Motor function depends on neural dynamics spanning multiple spatiotemporal scales of
population activity, from spiking of neurons to larger-scale local field potentials (LFP). How …