Modeling and experimental approaches for elucidating multi-scale uterine smooth muscle electro-and mechano-physiology: A review

AS Garrett, SA Means, MW Roesler, KJW Miller… - Frontiers in …, 2022 - frontiersin.org
The uterus provides protection and nourishment (via its blood supply) to a develo** fetus,
and contracts to deliver the baby at an appropriate time, thereby having a critical contribution …

Forces involved with labor and delivery—a biomechanical perspective

MJ Grimm - Annals of Biomedical Engineering, 2021 - Springer
Childbirth is a primarily biomechanical process of physiology, and one that engineers have
recently begun to address in a broader fashion. Computational models are being developed …

Chemo-mechanical modeling of smooth muscle cell activation for the simulation of arterial walls under changing blood pressure

K Uhlmann, D Balzani - Biomechanics and Modeling in Mechanobiology, 2023 - Springer
In this paper, a novel chemo-mechanical model is proposed for the description of the stretch-
dependent chemical processes known as Bayliss effect and their impact on the active …

Multiphysics and multiscale modeling of uterine contractions: integrating electrical dynamics and soft tissue deformation with fiber orientation

A Ballit, TT Dao - Medical & Biological Engineering & Computing, 2024 - Springer
The development of a comprehensive uterine model that seamlessly integrates the intricate
interactions between the electrical and mechanical aspects of uterine activity could …

An electro-mechanical multiscale model of uterine pregnancy contraction

M Yochum, J Laforêt, C Marque - Computers in biology and medicine, 2016 - Elsevier
Detecting preterm labor as early as possible is important because tocolytic drugs are much
more likely to delay preterm delivery if administered early. Having good information on the …

On the effect of irregular uterine activity during a vaginal delivery using an electro-chemo-mechanical constitutive model

DS Fidalgo, M Borges, MCPV Pouca… - Journal of the …, 2022 - Elsevier
During a normal vaginal delivery, the muscle cells propagate electrical signals throughout
the uterine wall, resulting in uterine contractions. However, uncoordinated uterine activity …

On the management of maternal pushing during the second stage of labor: a biomechanical study considering passive tissue fatigue damage accumulation

MCPV Pouca, JPS Ferreira, MPL Parente… - American journal of …, 2022 - Elsevier
Background During the second stage of labor, the maternal pelvic floor muscles undergo
repetitive stretch loading as uterine contractions and strenuous maternal pushes combined …

Simulation of the uterine contractions and foetus expulsion using a chemo-mechanical constitutive model

MCP Vila Pouca, JPS Ferreira, DA Oliveira… - … and Modeling in …, 2019 - Springer
During vaginal delivery women sustain stretching of their pelvic floor, risking tissue injury
and adverse outcomes. Since studies in pregnant women are limited with ethical constraints …

Equilibrium mechanical properties of the human uterus in tension and compression

S Fang, CA Duarte, DM Fodera, L Shi, X Chen… - Acta Biomaterialia, 2025 - Elsevier
A successful pregnancy relies on the proper cellular, biochemical, and mechanical functions
of the uterus. A comprehensive understanding of nonpregnant and pregnant uterine …

Multi-scale and multi-physics model of the uterine smooth muscle with mechanotransduction

M Yochum, J Laforêt, C Marque - Computers in biology and medicine, 2018 - Elsevier
Preterm labor is an important public health problem. However, the efficiency of the uterine
muscle during labor is complex and still poorly understood. This work is a first step towards a …