Periodontitis and osteoporosis are prevalent inflammation‐associated skeletal disorders that
pose significant public health challenges to our aging population. Both periodontitis and …

This authoritative survey discusses how tumor cells cause bone metastases by producing
both local and systemic factors that disrupt the balance between bone formation and bone …

A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which
chromosome translocations frequently place oncogenes under the control of …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …

Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Interleukin-6 (IL-6) and interleukin-11 (IL-11) are known to influence osteoclast formation
and bone resorption. In order to determine whether IL-6 and IL-11 could independently …

Bone disease in multiple myeloma (MM) is characterized by lytic bone lesions, which can
cause severe bone pain, pathologic fractures and hypercalcemia. However, the lytic bone …

The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming
osteoblasts. These two cell types are fundamentally different in terms of progenitor cells …