Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022‏ - Elsevier
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021‏ - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

R Singh, A Letai, K Sarosiek - Nature reviews Molecular cell biology, 2019‏ - nature.com
The loss of vital cells within healthy tissues contributes to the development, progression and
treatment outcomes of many human disorders, including neurological and infectious …

Ferroptosis and its potential role in human diseases

C Han, Y Liu, R Dai, N Ismail, W Su, B Li - Frontiers in pharmacology, 2020‏ - frontiersin.org
Ferroptosis is a novel regulated cell death pattern discovered when studying the mechanism
of erastin-killing RAS mutant tumor cells in 2012. It is an iron-dependent programmed cell …

Animal models of traumatic brain injury

Y **ong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013‏ - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury

L Zhong, J Wang, P Wang, X Liu, P Liu… - Stem cell research & …, 2023‏ - Springer
Regenerative repair of the brain after traumatic brain injury (TBI) remains an extensive
clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior …

Translational research in traumatic brain injury

D Laskowitz, G Grant - 2016‏ - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Mechanisms of action, physiological effects, and complications of hypothermia

KH Polderman - Critical care medicine, 2009‏ - journals.lww.com
Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Major depression following traumatic brain injury

RE Jorge, RG Robinson, D Moser… - Archives of general …, 2004‏ - jamanetwork.com
Backgroud Major depression is a frequent psychiatric complication among patients with
traumatic brain injury (TBI). To our knowledge, however, the clinical correlates of major …

Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury

H Algattas, JH Huang - International journal of molecular sciences, 2013‏ - mdpi.com
Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in
the population. While precise pathological mechanisms are lacking, the growing base of …