Alopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in
hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has …

Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …

Background Alopecia areata is an autoimmune condition characterized by rapid hair loss in
the scalp, eyebrows, and eyelashes, for which treatments are limited. Baricitinib, an oral …

We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair
loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in …

Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss. Significant
variations in the clinical presentation of AA have been observed, ranging from small, well …

Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex
immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in …

The maintenance of tissue homeostasis is critically dependent on the function of tissue-
resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs) …

Alopecia Areata (AA) is a common autoimmune disease characterized by non-scarring hair
loss ranging from patches on the scalp to complete hair loss involving the entire body …