Inflammatory processes in cardiovascular disease: a route to targeted therapies

N Ruparelia, JT Chai, EA Fisher… - Nature reviews …, 2017 - nature.com
Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Thrombosis formation on atherosclerotic lesions and plaque rupture

L Badimon, G Vilahur - Journal of internal medicine, 2014 - Wiley Online Library
Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of
cardiovascular ischaemic events. The evolution of vascular disease involves a combination …

Atherosclerotic carotid plaque composition and incident stroke and coronary events

D Bos, B Arshi, QJA van den Bouwhuijsen… - Journal of the American …, 2021 - jacc.org
Background Increasing evidence suggests that atherosclerotic plaque composition rather
than plaque size is linked to ischemic cardiovascular events, yet largescale population …

Inflammation and stroke risk: a new target for prevention

PJ Kelly, R Lemmens, G Tsivgoulis - Stroke, 2021 - Am Heart Assoc
New therapeutic approaches are required for secondary prevention of residual vascular risk
after stroke. Diverse sources of evidence support a causal role for inflammation in the …

Vasa vasorum angiogenesis: key player in the initiation and progression of atherosclerosis and potential target for the treatment of cardiovascular disease

DG Sedding, EC Boyle, JAF Demandt… - Frontiers in …, 2018 - frontiersin.org
Plaque microvascularization and increased endothelial permeability are key players in the
development of atherosclerosis, from the initial stages of plaque formation to the occurrence …

Role of melatonin in controlling angiogenesis under physiological and pathological conditions

Q Ma, RJ Reiter, Y Chen - Angiogenesis, 2020 - Springer
Angiogenesis depends on proangiogenic and anti-angiogenic molecules that regulate
endothelial cell proliferation and migration. Well-regulated angiogenesis plays a pivotal role …

Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the …

PH Stone, S Saito, S Takahashi, Y Makita… - Circulation, 2012 - Am Heart Assoc
Background—Atherosclerotic plaques progress in a highly individual manner. The purposes
of the Prediction of Progression of Coronary Artery Disease and Clinical Outcome Using …

The myth of the “vulnerable plaque” transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment

A Arbab-Zadeh, V Fuster - Journal of the American College of Cardiology, 2015 - jacc.org
The cardiovascular science community has pursued the quest to identify vulnerable
atherosclerotic plaque in patients for decades, ho** to prevent acute coronary events …

Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies

C Silvestre-Roig, MP De Winther, C Weber… - Circulation …, 2014 - Am Heart Assoc
Understanding the pathophysiology of atherogenesis and the progression of atherosclerosis
have been major goals of cardiovascular research during the previous decades. However …

Microparticles, vascular function, and atherothrombosis

PE Rautou, AC Vion, N Amabile, G Chironi… - Circulation …, 2011 - Am Heart Assoc
Membrane-shed submicron microparticles (MPs) are released after cell activation or
apoptosis. High levels of MPs circulate in the blood of patients with atherothrombotic …