There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Glioblastoma is the most common and most aggressive primary brain tumor. Despite
maximum treatment, patients only have a median survival time of 15 months, because of the …

We characterized the mutational landscape of melanoma, the form of skin cancer with the
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …

Purpose To define copy number alterations and gene expression signatures underlying
pediatric high-grade glioma (HGG). Patients and Methods We conducted a high-resolution …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes.
We have identified a clue to the mechanistic origins of aneuploidy through integrative …

The signal transducer and activator of transcription 3 (STAT3) protein is a major transcription
factor involved in many cellular processes, such as cell growth and proliferation …

Members of the protein tyrosine phosphatase (Ptp) family dephosphorylate target proteins
and counter the activities of protein tyrosine kinases that are involved in cellular …

Gliomas are the most common primary brain tumors. They account for more than 70% of all
neoplasms of the central nervous system and vary considerably in morphology, location …

Activation of cyclin-dependent kinases 4 and 6 (cdk4/6) occurs in the majority of
glioblastoma multiforme (GBM) tumors, and represents a promising molecular target for the …