To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

INTRODUCTION The interaction among cell-autonomous circadian oscillators—daily cycles
of activity–rest and feeding–fasting—produces diurnal rhythms in gene expression in almost …

A majority of mammalian genes exhibit daily fluctuations in expression levels, making
circadian expression rhythms the largest known regulatory network in normal physiology …

Life evolved with daily predictable changes in light, temperature, and food availability. With
sunlight being the primary source of energy for photosynthetic organisms, there was a strong …

Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are
controlled. While intermediary metabolites serve as co-factors for histone-modifying …

Circadian rhythm disruption (CD) is associated with impaired glucose homeostasis and type
2 diabetes mellitus (T2DM). While the link between CD and T2DM remains unclear, there is …

The circadian clock regulates numerous key physiological processes and maintains cellular,
tissue, and systemic homeostasis. Disruption of circadian clock machinery influences key …

The circadian cycle allows organisms to track external time of day and predict/respond to
changes in the external environment. In higher order organisms, circadian rhythmicity is a …

Background ATP-dependent chromatin remodelers are evolutionarily conserved complexes
that alter nucleosome positioning to influence many DNA-templated processes, such as …