The action of transforming-growth-factor (TGF)-β following inflammatory responses is
characterized by increased production of extracellular matrix (ECM) components, as well as …

The synovial joint contains synovial fluid (SF) within a cavity bounded by articular cartilage
and synovium. SF is a viscous fluid that has lubrication, metabolic, and regulatory functions …

We undertook a systematic study focused on the matricellular protein Thrombospondin-1
(THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune
cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still …

Fibrosis and scar formation results from chronic progressive injury in virtually every tissue
and affects a growing number of people around the world. Myofibroblasts drive fibrosis, and …

Thrombospondin 1 (TSP1) plays major roles in both physiologic and pathologic tissue
repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-β activation and …

Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two
main cellular components of the synovium. It has been widely reported that FLS and MLS …

Fibroblast-like synoviocytes (FLSs) are important non-immune cells located mostly in the
inner layer of the synovium. Indeed, these cells are specialized mesenchymal cells …

Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …

Deciphering transcription factor networks from microarray data remains difficult. This study
presents a simple method to infer the regulation of transcription factors from microarray data …