Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic
dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of …

Genetic instability can be caused by external factors and may also be associated with
intracellular damage. At the same time, there is a large body of research investigating the …

Cancer is a devastating disease that claims over 8 million lives each year. Understanding
the molecular etiology of the disease is critical to identify and develop new therapeutic …

Somatic copy number amplification and gene overexpression are common features of many
cancers. To determine the role of gene overexpression on chromosome instability (CIN), we …

Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its
immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that …

Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer.
Canonical Hh signaling is mediated by Hh ligand binding to the receptor Patched (Ptch) …

Cystic fibrosis (CF) has a profound impact on airway physiology. Accumulating evidence
suggests that intercellular junctions are impaired in CF. We examined changes to CF …

The study of immune responses in Drosophila has already yielded significant results with
impacts on our understanding of vertebrate immunity, such as the characterization of the Toll …

Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer.
Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all …

An increase in centrosome number is commonly observed in cancer cells, but the role
centrosome amplification plays along with how and when it occurs during cancer …