The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Exosomes are vesicles encompassed by a lipid bilayer that are released by various living
cells. Exosomal proteins are encapsulated within the membrane or embedded on the …

We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …

Genomic analyses in cancer have been enormously impactful, leading to the identification of
driver mutations and development of targeted therapies. But the functions of the vast majority …

Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal
cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and …

Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the
poorest prognosis among gynecological malignancies. Because of the absence of specific …

A plethora of software suites and multiple classes of spectral libraries have been developed
to enhance the depth and robustness of data-independent acquisition (DIA) data …

Neoplasms are one of the most concerned public health problems worldwide. Digestive
system neoplasms, with a high morbidity and mortality, is one of the most common malignant …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Serial multi-omic analysis of proteome, phosphoproteome, and acetylome provides insights
into changes in protein expression, cell signaling, cross-talk and epigenetic pathways …