Insulin receptor isoforms in physiology and disease: an updated view
A Belfiore, R Malaguarnera, V Vella… - Endocrine …, 2017 - academic.oup.com
The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …
MBNL proteins and their target RNAs, interaction and splicing regulation
P Konieczny, E Stepniak-Konieczna… - Nucleic acids …, 2014 - academic.oup.com
Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA
metabolism in mammals. Based on published and novel data, we explore models of tissue …
metabolism in mammals. Based on published and novel data, we explore models of tissue …
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common
drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to …
drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to …
[HTML][HTML] OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer
J Li, D Cheng, M Zhu, H Yu, Z Pan, L Liu, Q Geng… - Theranostics, 2019 - ncbi.nlm.nih.gov
Increasing evidence has confirmed that deubiquitinating enzymes play an important role in
lung cancer progression. In the current study, we investigated the expression profile of …
lung cancer progression. In the current study, we investigated the expression profile of …
[HTML][HTML] Myotonic dystrophy type 1
TD Bird - 2021 - europepmc.org
Myotonic dystrophy type 1 (DM1) is a multisystem disorder that affects skeletal and smooth
muscle as well as the eye, heart, endocrine system, and central nervous system. The clinical …
muscle as well as the eye, heart, endocrine system, and central nervous system. The clinical …
In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors
FXR Sutandy, S Ebersberger, L Huang… - Genome …, 2018 - genome.cshlp.org
Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in
eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it …
eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it …
Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival
P Malakar, L Chartarifsky, A Hija, G Leibowitz… - Scientific reports, 2016 - nature.com
Abstract Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of
the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin …
the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin …
Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator
We report the detailed transcriptomic profiles of human innate myeloid cells using RNA
sequencing. Monocytes migrate from blood into infected or wounded tissue to differentiate …
sequencing. Monocytes migrate from blood into infected or wounded tissue to differentiate …
Gamma-glutamyl-leucine levels are causally associated with elevated cardio-metabolic risks
Q Wu, J Li, J Zhu, X Sun, D He, J Li, Z Cheng… - Frontiers in …, 2022 - frontiersin.org
Objective Gamma-glutamyl dipeptides are bioactive peptides involved in inflammation,
oxidative stress, and glucose regulation. Gamma-glutamyl-leucine (Gamma-Glu-Leu) has …
oxidative stress, and glucose regulation. Gamma-glutamyl-leucine (Gamma-Glu-Leu) has …
MBNL1 alternative splicing isoforms play opposing roles in cancer
The extent of and the oncogenic role played by alternative splicing (AS) in cancer are well
documented. Nonetheless, only few studies have attempted to dissect individual gene …
documented. Nonetheless, only few studies have attempted to dissect individual gene …