Uterine adenomyosis: from disease pathogenesis to a new medical approach using GnRH antagonists

J Donnez, CA Stratopoulou, MM Dolmans - International journal of …, 2021 - mdpi.com
Uterine adenomyosis is a common chronic disorder frequently encountered in reproductive-
age women, causing heavy menstrual bleeding, intense pelvic pain, and infertility. Despite …

Androgens, oestrogens and endometrium: a fine balance between perfection and pathology

DA Gibson, I Simitsidellis, F Collins… - Journal of …, 2020 - joe.bioscientifica.com
The endometrium is a complex multicellular tissue that is exquisitely sensitive to the actions
of sex steroids synthesised in the ovary (endocrine system). Recent studies have highlighted …

[HTML][HTML] Various types of adenomyosis and endometriosis: in search of optimal management

SW Guo - Fertility and Sterility, 2023 - Elsevier
Currently, hormonal drugs are the mainstay for treating endometriosis or adenomyosis.
Aside from staying within the “therapeutic window” and cutting off the hormonal support to …

The role of abnormal uterine junction zone in the occurrence and development of adenomyosis

T **e, X Xu, Y Yang, C Wu, X Liu, L Zhou, Y Song - Reproductive Sciences, 2021 - Springer
Adenomyosis is a benign disease with a malignant behavior, bothering a lot of women at
reproductive age who suffer from increased menstruation, prolonged menstruation …

Decreased expression of cannabinoid receptors in the eutopic and ectopic endometrium of patients with adenomyosis

X Shen, H Duan, S Wang, L Gan… - BioMed Research …, 2019 - Wiley Online Library
Objective. Adenomyosis is a common gynecologic benign disease that may have a life‐long
negative impact on women. Previous studies have indicated that the endocannabinoid …

Chronic GPER1 activation protects against oxidative stress-induced cardiomyoblast death via preservation of mitochondrial integrity and deactivation of mammalian …

A Imam Aliagan, NB Madungwe, N Tombo… - Frontiers in …, 2020 - frontiersin.org
Introduction: Estrogen (17β-estradiol, E2) is well-known to induce cardioprotective effects
against ischemia/reperfusion (I/R) injury. We recently reported that acute application of E2 at …

[HTML][HTML] The Mechanism Involved in the Inhibition of Resveratrol and Genistein on the Contractility of Isolated Rat Uterus Smooth Muscle

Q Ma, Y Wang, W Zhang, Z Du, Z Tian, H Li - Nutrients, 2024 - mdpi.com
Purpose: This study aimed to compare the effects of the phytoestrogens resveratrol (RES)
and genistein (GEN) on the contractility of isolated uterine smooth muscle from rats, focusing …

RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface

Z Guo, H Duan, S Wang, S Wang, Q Lin, Y Li - BMC Women's Health, 2022 - Springer
Background Uterine adenomyosis is associated with chronic pelvic pain, abnormal uterine
bleeding, and infertility. The pathogenesis of adenomyosis is still unclear. Circular RNAs …

The Cellular Respiration of Endometrial Biopsies from Patients with Various Forms of Endometriosis

KA Toniyan, AA Malkov, NS Biryukov… - International Journal of …, 2024 - mdpi.com
Endometriosis is one of the leading pathologies of the reproductive system of women of
fertile age, which shows changes in cell metabolism in the lesions. We conducted a study of …

The immunohistochemical expression of GPER and classical sex hormone receptors differs in adenomyosis and eutopic endometrium

N Samartzis, DR Kalaitzopoulos, A Noske… - Journal of Reproductive …, 2023 - Elsevier
G protein-coupled estrogen receptor (GPER) has been found to be an important key
regulator in the homeostasis of sex hormone-dependent human cells. The aim of this study …