Because of the extensive biological functions of natural substances such as bioflavonoids,
and their high safety and low costs, they could have high priority application in the health …

Abstract Parkinson's disease (PD), a neurodegenerative disease that shows a high
incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no …

Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat
diseases related to central nervous system (CNS) damage. However, the blood‐brain …

Neurodegenerative diseases are a major global health burden particularly with the
increasing ageing population. Hereditary predisposition and environmental risk factors …

The biggest obstacle to the treatment of diseases that affect the central nervous system
(CNS) is the passage of drugs across the blood-brain barrier (BBB), a physical barrier that …

Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

Atazanavir (ATZ) presents poor brain availability when administered orally, which poses a
major hurdle in its use as an effective therapy for the management of NeuroAIDS. The …

Flavonoids are compounds abundantly found in nature and known as a polyphenolic group
of compounds having flavancore and show the utmost abundant collection of complexes …

Rutin, a hydrophobic flavonoid found in various fruits and vegetables, has potential health
benefits. However, its therapeutic use is limited due to poor bioavailability and stability …

Aging is spontaneous and inevitable process in all living beings. It is a complex natural
phenomenon that manifests as a gradual decline of physiological functions and …