The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases ranging from
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its
prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 …

Abstract Background and Aims Peroxisome proliferator–activated receptor α (PPARα,
NR1C1) is a ligand‐activated nuclear receptor involved in the regulation of lipid catabolism …

Conclusions ALI with therapeutic doses of APAP is associated with more severe liver injury
than overdose. It only occurs in patients with excess drinking and/or fasting. A warning …

Schisandrin A (SA) is a bioactive lignan isolated from the traditional Chinese medicine
Fructus schisandrae chinensis. In recent years, it has attracted extensive attention because …

Background and Aims The Hippo pathway and its downstream effectors YAP and TAZ
(YAP/TAZ) are heralded as important regulators of organ growth and regeneration …

Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two nuclear
receptors that are well-known for their roles in xenobiotic detoxification by regulating the …

Cell death is a vital physiological or pathological phenomenon in the development process
of the organism. Ferroptosis is a kind of newly-discovered regulated cell death (RCD), which …