[HTML][HTML] Iron in infection and immunity
M Nairz, G Weiss - Molecular Aspects of Medicine, 2020 - Elsevier
Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …
invading pathogens and mammalian cells including those of the immune system require iron …
Engineered EVs designed to target diseases of the CNS
Diseases of the central nervous system (CNS) are challenging to treat, mainly due to the
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …
blood-brain barrier (BBB), which restricts drugs in circulation from entering target regions in …
Iron Acquisition in Mycobacterium tuberculosis
The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …
Comprehensive analysis of iron utilization by Mycobacterium tuberculosis
L Zhang, RC Hendrickson, V Meikle… - PLoS …, 2020 - journals.plos.org
Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …
Bacterial excretion of cytoplasmic proteins (ECP): occurrence, mechanism, and function
The excretion of cytoplasmic and signal-peptide-less proteins (ECP) by microorganisms and
eukaryotes remains a fascinating topic. In principle, it appears to be a waste of energy …
eukaryotes remains a fascinating topic. In principle, it appears to be a waste of energy …
Antituberculosis targeted drug delivery as a potential future treatment approach
Mycobacterium tuberculosis (Mtb) is the microorganism that causes tuberculosis. This
infectious disease has been around for centuries, with the earliest record of Mtb around …
infectious disease has been around for centuries, with the earliest record of Mtb around …
Diverse localization and protein binding abilities of glyceraldehyde-3-phosphate dehydrogenase in pathogenic bacteria: the key to its multifunctionality?
M Kopeckova, I Pavkova, J Stulik - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Bacterial proteins exhibiting two or more unrelated functions, referred to as moonlighting
proteins, are suggested to contribute to full virulence manifestation in pathogens. An …
proteins, are suggested to contribute to full virulence manifestation in pathogens. An …
Antimicrobial peptides as potential anti-tubercular leads: a concise review
GS Oliveira, RP Costa, P Gomes, MS Gomes, T Silva… - Pharmaceuticals, 2021 - mdpi.com
Despite being considered a public health emergency for the last 25 years, tuberculosis (TB)
is still one of the deadliest infectious diseases, responsible for over a million deaths every …
is still one of the deadliest infectious diseases, responsible for over a million deaths every …
Regulation of macrophage cell surface GAPDH alters LL-37 internalization and downstream effects in the cell
Abstract Mycobacterium tuberculosis (M. tb), the major causative agent of tuberculosis, has
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …
evolved mechanisms to evade host defenses and persist within host cells. Host-directed …
Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake
R de Miranda, BJ Cuthbert, T Klevorn, A Chao… - PLoS …, 2023 - journals.plos.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, poses a great threat
to human health. With the emergence of drug resistant Mtb strains, new therapeutics are …
to human health. With the emergence of drug resistant Mtb strains, new therapeutics are …