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The biology of ependymomas and emerging novel therapies
Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …
The oncogenic fusion landscape in pediatric CNS neoplasms
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …
related deaths in children. Recent developments in molecular analyses have greatly …
Childhood supratentorial ependymomas with YAP1‐MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features
Ependymoma with YAP1‐MAMLD1 fusion is a rare, recently described supratentorial
neoplasm of childhood, with few cases published so far. We report on 15 pediatric patients …
neoplasm of childhood, with few cases published so far. We report on 15 pediatric patients …
Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion–positive supratentorial ependymomas
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA–RELA or
YAP1-involving fusions and fusion-negative subependymoma. However, occasionally …
YAP1-involving fusions and fusion-negative subependymoma. However, occasionally …
Recurrent YAP1 and KMT2A gene rearrangements in a subset of MUC4-negative sclerosing epithelioid fibrosarcoma
YC Kao, JC Lee, L Zhang, YS Sung… - The American journal …, 2020 - journals.lww.com
Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma,
characterized by a distinctive epithelioid phenotype in a densely sclerotic collagenous …
characterized by a distinctive epithelioid phenotype in a densely sclerotic collagenous …
Ependymoma‐like tumor with mesenchymal differentiation harboring C11orf95‐NCOA1/2 or ‐RELA fusion: A hitherto unclassified tumor related to ependymoma
R Tomomasa, Y Arai, R Kawabata‐Iwakawa… - Brain …, 2021 - Wiley Online Library
Recurrent fusion genes involving C11orf95, C11orf95‐RELA, have been identified only in
supratentorial ependymomas among primary CNS tumors. Here, we report hitherto …
supratentorial ependymomas among primary CNS tumors. Here, we report hitherto …
[HTML][HTML] Molecular stratification of childhood ependymomas as a basis for personalized diagnostics and treatment
M Zaytseva, L Papusha, G Novichkova, A Druy - Cancers, 2021 - mdpi.com
Simple Summary The current trend in neuropathology directs to the integrated histo-
molecular approach. The traditional concept of histological grade should be complemented …
molecular approach. The traditional concept of histological grade should be complemented …
Molecular subty** of ependymoma and prognostic impact of Ki-67
Although ependymomas (EPNs) have similar histopathology, they are heterogeneous
tumors with diverse immunophenotypes, genetics, epigenetics, and different clinical …
tumors with diverse immunophenotypes, genetics, epigenetics, and different clinical …
Fusion genes as biomarkers in pediatric cancers: a review of the current state and applicability in diagnostics and personalized therapy
The incidence of pediatric cancers is rising steadily across the world, along with the
challenges in understanding the molecular mechanisms and devising effective therapeutic …
challenges in understanding the molecular mechanisms and devising effective therapeutic …
Intracranial ependymomas: molecular insights and translation to treatment
A Lester, KL McDonald - Brain Pathology, 2020 - Wiley Online Library
Ependymomas are primary central nervous system tumors (CNS), arising within the
posterior fossa and supratentorial regions of the brain, and in the spine. Over the last …
posterior fossa and supratentorial regions of the brain, and in the spine. Over the last …