Among diverse actinobacteria, Streptomyces is a renowned ongoing source for the
production of a large number of secondary metabolites, furnishing immeasurable …

Highlights•Advanced genomic manipulation tools in actinomycetes enable streamlined
engineering of primary and secondary metabolism.•Advances in engineering of …

Covering: 2012 to 2016 Metabolic engineering using systems biology tools is increasingly
applied to overproduce secondary metabolites for their potential industrial production. In this …

Chrysomycin A is one of the valuable drug leads used to treat infectious diseases such as
tuberculosis and methicillin-resistant Staphylococcus aureus. In order to increase its yield …

Branched chain amino acids (BCAA) are catabolized into various acyl-CoA compounds,
which are key precursors used in polyketide productions. Because of that, BCAA catabolism …

Streptomyces are the most prolific source of structurally diverse microbial natural products.
Advancing genome-based analysis reveals the previously unseen potential of Streptomyces …

Antibiotic production in Actinobacteria is highly coordinated and subject to diverse
environmental and physiological (pre) conditions. Several general factors are known to …

An effective experimental design is a crucial element in the development of any product or
process. It hinges on a comprehensive understanding of the system being studied …

Aromatic nitro compounds are key building blocks for many industrial syntheses and are
also components of explosives, drugs and pesticides. Due to the environmentally unfriendly …

Streptomyces hydrogenans is well known to exhibit antagonistic activity against several
fungal pathogens. However, improving the potency of such inhibitory activity is challenging …