The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design

W Fleri, S Paul, SK Dhanda, S Mahajan, X Xu… - Frontiers in …, 2017 - frontiersin.org
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics
analytic tools and access to depositories of curated data relevant to immune reactions and …

SARS-CoV-2 vaccine development: current status

GA Poland, IG Ovsyannikova, SN Crooke… - Mayo Clinic …, 2020 - Elsevier
In the midst of the severe acute respiratory syndrome coronavirus 2 pandemic and its
attendant morbidity and mortality, safe and efficacious vaccines are needed that induce …

In silico validation of the non‐antibiotic drugs acetaminophen and ibuprofen as antibacterial agents against red complex pathogens

J Vijayashree Priyadharsini - Journal of periodontology, 2019 - Wiley Online Library
Background Acetaminophen (APAP) and ibuprofen (IB) are drugs commonly used to
alleviate pain due to their anti‐inflammatory, anti‐pyretic, and analgesic effect. The aim of …

BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes

MC Jespersen, B Peters, M Nielsen… - Nucleic acids …, 2017 - academic.oup.com
Antibodies have become an indispensable tool for many biotechnological and clinical
applications. They bind their molecular target (antigen) by recognizing a portion of its …

IEDB-AR: immune epitope database—analysis resource in 2019

SK Dhanda, S Mahajan, S Paul, Z Yan… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools. iedb. org/)
is a companion website to the IEDB that provides computational tools focused on the …

BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models

JN Clifford, MH Høie, S Deleuran, B Peters… - Protein …, 2022 - Wiley Online Library
B‐cell epitope prediction tools are of great medical and commercial interest due to their
practical applications in vaccine development and disease diagnostics. The introduction of …

Contriving multi-epitope subunit of vaccine for COVID-19: immunoinformatics approaches

R Dong, Z Chu, F Yu, Y Zha - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 has recently become the most serious threat to public health, and its prevalence
has been increasing at an alarming rate. The incubation period for the virus is~ 1–14 days …

Exploring Leishmania secretory proteins to design B and T cell multi-epitope subunit vaccine using immunoinformatics approach

N Khatoon, RK Pandey, VK Prajapati - Scientific reports, 2017 - nature.com
Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries,
worldwide. Increasing drug resistance, HIV co-infection, and poor health system require …

Targeted isolation and cultivation of uncultivated bacteria by reverse genomics

KL Cross, JH Campbell, M Balachandran… - Nature …, 2019 - nature.com
Most microorganisms from all taxonomic levels are uncultured. Single-cell genomes and
metagenomes continue to increase the known diversity of Bacteria and Archaea; however …

An introduction to B‐cell epitope map** and in silico epitope prediction

L Potocnakova, M Bhide… - Journal of immunology …, 2016 - Wiley Online Library
Identification of B‐cell epitopes is a fundamental step for development of epitope‐based
vaccines, therapeutic antibodies, and diagnostic tools. Epitope‐based antibodies are …