Decoding the brain: From neural representations to mechanistic models

MW Mathis, AP Rotondo, EF Chang, AS Tolias… - Cell, 2024‏ - cell.com
A central principle in neuroscience is that neurons within the brain act in concert to produce
perception, cognition, and adaptive behavior. Neurons are organized into specialized brain …

Analysis methods for large-scale neuronal recordings

C Stringer, M Pachitariu - Science, 2024‏ - science.org
Simultaneous recordings from hundreds or thousands of neurons are becoming routine
because of innovations in instrumentation, molecular tools, and data processing software …

A unified, scalable framework for neural population decoding

M Azabou, V Arora, V Ganesh, X Mao… - Advances in …, 2023‏ - proceedings.neurips.cc
Our ability to use deep learning approaches to decipher neural activity would likely benefit
from greater scale, in terms of both the model size and the datasets. However, the …

Population-level coding of avoidance learning in medial prefrontal cortex

B Ehret, R Boehringer, EA Amadei, MR Cervera… - Nature …, 2024‏ - nature.com
The medial prefrontal cortex (mPFC) has been proposed to link sensory inputs and
behavioral outputs to mediate the execution of learned behaviors. However, how such a link …

De novo motor learning creates structure in neural activity that shapes adaptation

JC Chang, MG Perich, LE Miller, JA Gallego… - Nature …, 2024‏ - nature.com
Animals can quickly adapt learned movements to external perturbations, and their existing
motor repertoire likely influences their ease of adaptation. Long-term learning causes lasting …

Soft Matching Distance: A metric on neural representations that captures single-neuron tuning

M Khosla, AH Williams - … of UniReps: the First Workshop on …, 2024‏ - proceedings.mlr.press
Common measures of neural representational (dis) similarity are designed to be insensitive
to rotations and reflections of the neural activation space. Motivated by the premise that the …

Modeling and dissociation of intrinsic and input-driven neural population dynamics underlying behavior

P Vahidi, OG Sani, MM Shanechi - … of the National Academy of Sciences, 2024‏ - pnas.org
Neural dynamics can reflect intrinsic dynamics or dynamic inputs, such as sensory inputs or
inputs from other brain regions. To avoid misinterpreting temporally structured inputs as …

Conjoint specification of action by neocortex and striatum

J Park, P Polidoro, C Fortunato, J Arnold, B Mensh… - Neuron, 2025‏ - cell.com
The interplay between two major forebrain structures—cortex and subcortical striatum—is
critical for flexible, goal-directed action. Traditionally, it has been proposed that striatum is …

[HTML][HTML] Integrating across behaviors and timescales to understand the neural control of movement

JM Gmaz, JA Keller, JT Dudman, JA Gallego - Current Opinion in …, 2024‏ - Elsevier
The nervous system evolved to enable navigation throughout the environment in the pursuit
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …