Translating insights into therapies for Long Covid

AAR Antar, AL Cox - Science translational medicine, 2024 - science.org
Long Covid is defined by a wide range of symptoms that persist after the acute phase of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …

Challenges and opportunities in long COVID research

RE Hamlin, CA Blish - Immunity, 2024 - cell.com
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-
CoV-2 infection but rather have persistent or new symptoms for months to years following …

Intrinsic factors behind long‐COVID: II. SARS‐CoV‐2, extracellular vesicles, and neurological disorders

YA El‐Maradny, A Rubio‐Casillas… - Journal of Cellular …, 2023 - Wiley Online Library
With the decline in the number of new Severe Acute Respiratory Syndrome Coronavirus 2
(SARS‐CoV‐2) infections, the World Health Organization announced the end of the SARS …

Translocator protein (TSPO) is a biomarker of Zika virus (ZIKV) infection-associated neuroinflammation

CBL Victorio, A Ganasarajah, W Novera… - Emerging Microbes & …, 2024 - Taylor & Francis
Zika is a systemic inflammatory disease caused by infection with Zika virus (ZIKV). ZIKV
infection in adults is associated with encephalitis marked by elevated expression of pro …

Beyond acute infection: mechanisms underlying post‐acute sequelae of COVID‐19 (PASC)

A Adhikari, J Maddumage, EM Eriksson… - Medical Journal of …, 2024 - Wiley Online Library
Immune dysregulation is a key aspect of post‐acute sequelae of coronavirus disease 2019
(PASC), also known as long COVID, with sustained activation of immune cells, T cell …

Neuroinflammation in Post COVID‐19 Sequelae: Neuroinvasion and Neuroimmune Crosstalk

RS Dos Reis, S Selvam… - Reviews in Medical …, 2024 - Wiley Online Library
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in
December 2019 triggered a swift global spread, leading to a devastating pandemic …

Brain fog in long COVID: a glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism

T Horowitz, L Pellerin, ER Zimmer, E Guedj - Medical Hypotheses, 2023 - Elsevier
Abstract Brain [18 F] FDG-PET scans have revealed a glucose hypometabolic pattern in
patients with long COVID. This hypometabolism might reflect primary astrocyte dysfunction …

Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance in acute …

Z Kikinis, A Castañeyra-Perdomo… - Frontiers in …, 2024 - frontiersin.org
Current views on immunity support the idea that immunity extends beyond defense functions
and is tightly intertwined with several other fields of biology such as virology, microbiology …

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

A Aggarwal, C Fichter, V Milogiannakis, T Ison… - Biorxiv, 2023 - biorxiv.org
Continued high-level spread of SARS-CoV-2 has enabled an accumulation of changes
within the Spike glycoprotein, leading to resistance to neutralising antibodies and …

[HTML][HTML] Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19

A Vanderheiden, MS Diamond - Viruses, 2025 - mdpi.com
Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes
driven by dysfunction of multiple organ systems that can persist for years and negatively …