[HTML][HTML] Advanced human developmental toxicity and teratogenicity assessment using human organoid models
M Li, J Gong, L Gao, T Zou, J Kang, H Xu - … and Environmental Safety, 2022 - Elsevier
Tremendous progress has been made in the field of toxicology leading to the advance of
developmental toxicity assessment. Conventional animal models and in vitro two …
developmental toxicity assessment. Conventional animal models and in vitro two …
Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments
Glioblastoma is the deadliest form of brain cancer. Aside from inadequate treatment options,
one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled …
one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled …
HiPSC-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs
The poor predictive power of existing preclinical models has spurred efforts to develop
human-relevant models for accurate assessment of drug safety. In this work, we developed a …
human-relevant models for accurate assessment of drug safety. In this work, we developed a …
Tailoring biomaterials for biomimetic organs-on-chips
Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes
The development of implantable neuroelectrodes is advancing rapidly as these tools are
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
The impact of emerging contaminants exposure on human health effects: A review of organoid assessment models
J Yang, X Zhang, Z Liu, C Yang, S Li, H Zhou… - Chemical Engineering …, 2024 - Elsevier
With the development of industrialization and modernization, the exposure risk of emerging
contaminants in the environment has inevitably increased. However, compared with …
contaminants in the environment has inevitably increased. However, compared with …
[HTML][HTML] Combining additive manufacturing with microfluidics: an emerging method for develo** novel organs-on-chips
Additive manufacturing (AM) or 3D printing is an ideal technology for building flexible,
complex, monolithic devices. Organs-on-chips (OOCs) are biomimetic microsystems that …
complex, monolithic devices. Organs-on-chips (OOCs) are biomimetic microsystems that …
Toxic effects and mechanisms of nanoplastics on embryonic brain development using brain organoids model
S Chen, Y Chen, Y Gao, B Han, T Wang, H Dong… - Science of the Total …, 2023 - Elsevier
Nanoplastics can be easily absorbed into the human body through inhalation, ingestion, and
skin contact due to their physicochemical property. Despite the numerous studies …
skin contact due to their physicochemical property. Despite the numerous studies …
[HTML][HTML] Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages
C Hu, S Yang, T Zhang, Y Ge, Z Chen, J Zhang… - Environment …, 2024 - Elsevier
An increasing number of harmful environmental factors are causing serious impacts on
human health, and there is an urgent need to accurately identify the toxic effects and …
human health, and there is an urgent need to accurately identify the toxic effects and …
Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model
Prenatal exposure to environmental insults can increase the risk of develo**
neurodevelopmental disorders. Administration of the antiepileptic drug valproic acid (VPA) …
neurodevelopmental disorders. Administration of the antiepileptic drug valproic acid (VPA) …