Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live
for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly …

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for
identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple …

Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …

Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

Both poikilotherms and homeotherms live longer at lower body temperatures, highlighting a
general role of temperature reduction in lifespan extension. However, the underlying …

Of all the age-related declines, memory loss is one of the most devastating. While conditions
that increase longevity have been identified, the effects of these longevity-promoting factors …

Neither genetic nor environmental factors fully account for variability in individual longevity:
genetically identical invertebrates in homogenous environments often experience no less …

This article describes the fabrication of a microfluidic device for the liquid culture of many
individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber …