Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated
with inflammation. ER stress can trigger inflammation through nucleotide-binding domain …

Clearance of cellular debris is required to maintain the homeostasis of multicellular
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …