Long-term diabetes increases the likelihood of develo** secondary damage to numerous
systems, and these complications represent a substantial cause of morbidity and mortality …

A number of proteomic and peptidomic analyses of urine from diabetic subjects have been
published in the quest for a biomarker that predicts progression of nephropathy. Less …

The use of reliable biomarkers is becoming increasingly important for the improved
management of patients with acute and chronic kidney diseases. Recent developments …

Proteomic biomarkers offer the hope of improving the management of patients with kidney
diseases by enabling more accurate and earlier detection of renal pathology than is …

Aims/hypothesis Microalbuminuria is considered the first clinical sign of kidney dysfunction
and is associated with a poor renal and cardiovascular prognosis in type 2 diabetes …

Identification of new biomarkers specific for various pathological conditions is an important
field in medical sciences. Body fluids have emerging potential in biomarker studies …

The prevalence of end-stage kidney disease (ESKD) continuously increases worldwide. The
increasing prevalence parallels the growth in the number of people with diabetes, which is …

Proposed molecular classifiers may be overfit to idiosyncrasies of noisy genomic and
proteomic data. Cross-validation methods are often used to obtain estimates of classification …

OBJECTIVE Chronic renal insufficiency and/or proteinuria in type 2 diabetes may stem from
chronic renal diseases (CKD) other than classic diabetic nephropathy in more than one-third …

Biomarker discovery approaches in urine have been hindered by concerns for
reproducibility and inadequate standardization of proteomics protocols. In this study, we …