New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Bacillus velezensis FZB42 in 2018: The Gram-Positive Model Strain for Plant Growth Promotion and Biocontrol

B Fan, C Wang, X Song, X Ding, L Wu, H Wu… - Frontiers in …, 2018 - frontiersin.org
Bacillus velezensis FZB42, the model strain for Gram-positive plant-growth-promoting and
biocontrol rhizobacteria, has been isolated in 1998 and sequenced in 2007. In order to …

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification

K Blin, T Wolf, MG Chevrette, X Lu… - Nucleic acids …, 2017 - academic.oup.com
Many antibiotics, chemotherapeutics, crop protection agents and food preservatives
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

JI Tietz, CJ Schwalen, PS Patel, T Maxson… - Nature chemical …, 2017 - nature.com
Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products
are attractive for genome-driven discovery and re-engineering, but limitations in …

The antiSMASH database version 3: increased taxonomic coverage and new query features for modular enzymes

K Blin, S Shaw, SA Kautsar, MH Medema… - Nucleic acids …, 2021 - academic.oup.com
Microorganisms produce natural products that are frequently used in the development of
antibacterial, antiviral, and anticancer drugs, pesticides, herbicides, or fungicides. In recent …

Secondary metabolite production and the safety of industrially important members of the Bacillus subtilis group

CR Harwood, JM Mouillon, S Pohl… - FEMS microbiology …, 2018 - academic.oup.com
Members of the 'Bacillus subtilis group'include some of the most commercially important
bacteria, used for the production of a wide range of industrial enzymes and fine …

The antiSMASH database version 4: additional genomes and BGCs, new sequence-based searches and more

K Blin, S Shaw, MH Medema, T Weber - Nucleic acids research, 2024 - academic.oup.com
Many microorganisms produce natural products that are frequently used in the development
of medicines and crop protection agents. Genome mining has evolved into a prominent …

The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters

K Blin, V Pascal Andreu, ELC de los Santos… - Nucleic acids …, 2019 - academic.oup.com
Natural products originating from microorganisms are frequently used in antimicrobial and
anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing …

Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

EJN Helfrich, CM Vogel, R Ueoka, M Schäfer… - Nature …, 2018 - nature.com
Plants are colonized by phylogenetically diverse microorganisms that affect plant growth
and health. Representative genome-sequenced culture collections of bacterial isolates from …