Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

CB2 was first considered to be the 'peripheral cannabinoid receptor'. This title was bestowed
based on its abundant expression in the immune system and presumed absence from the …

Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …

Receptor internalization increases the flexibility and scope of G protein-coupled receptor
(GPCR) signaling. CB 1 and CB 2 cannabinoid receptors undergo internalization after …

We disclose a general method for selective ortho-C–H arylation of cyclic and N, N-dialkyl
benzamides with boronic acids enabled by versatile ruthenium (II) complexes. This method …

The endogenous cannabinoids anandamide and 2-arachidonoylglycerol bind to the
cannabinoid receptors of type 1 and 2. These receptors are also the binding sites for …

Activation of cannabinoid CB 2 receptors suppresses neuropathic pain induced by traumatic
nerve injury. The present studies were conducted to evaluate the efficacy of cannabinoid CB …

Background: Chemotherapeutic agents produce dose-limiting peripheral neuropathy
through mechanisms that remain poorly understood. We previously showed that AM1710, a …

Spinal glial and proinflammatory cytokine actions are strongly implicated in pathological
pain. Spinal administration of the anti-inflammatory cytokine interleukin (IL)-10 abolishes …

Cannabinoid CB2 receptor agonists are in development as therapeutic agents, including for
immune modulation and pain relief. Despite promising results in rodent preclinical studies …