Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions
Nitric oxide and other redox active molecules such as oxygen free radicals provide essential
signalling in diverse neuronal functions, but their excess production and insufficient …
signalling in diverse neuronal functions, but their excess production and insufficient …
Copper drives prion protein phase separation and modulates aggregation
Prion diseases are characterized by prion protein (PrP) transmissible aggregation and
neurodegeneration, which has been linked to oxidative stress. The physiological function of …
neurodegeneration, which has been linked to oxidative stress. The physiological function of …
[HTML][HTML] Nitric oxide signaling and sensing in age-related diseases
O Mazuryk, I Gurgul, M Oszajca, J Polaczek… - …, 2024 - pmc.ncbi.nlm.nih.gov
Nitric oxide (NO) is a key signaling molecule involved in numerous physiological and
pathological processes within the human body. This review specifically examines the …
pathological processes within the human body. This review specifically examines the …
[HTML][HTML] Hydralazine inhibits neuroinflammation and oxidative stress in APP/PS1 mice via TLR4/NF-κB and Nrf2 pathways
Y Wang, J Zou, Y Wang, J Wang, X Ji, T Zhang… - …, 2023 - Elsevier
Alzheimer's disease (AD) is a common chronic progressive neurodegenerative disorder,
and curative treatment has not been developed. The objective of this study was to …
and curative treatment has not been developed. The objective of this study was to …
A multipurpose metallophore and its copper complexes with diverse catalytic antioxidant properties to deal with metal and oxidative stress disorders: A combined …
LB Menezes, RMSN Sampaio, L Meurer… - Inorganic …, 2024 - ACS Publications
We report the discovery that the molecule 1-(pyridin-2-ylmethylamino) propan-2-ol (HL) can
reduce oxidative stress in neuronal C6 glioma cells exposed to reactive oxygen species (O2 …
reduce oxidative stress in neuronal C6 glioma cells exposed to reactive oxygen species (O2 …
Redox mechanisms and their pathological role in prion diseases: The road to ruin
Prion diseases, also known as transmissible spongiform encephalopathies, are rare,
progressive, and fatal neurodegenerative disorders, which are caused by the accumulation …
progressive, and fatal neurodegenerative disorders, which are caused by the accumulation …
[HTML][HTML] Αnti-prion effects of anthocyanins
N Christoudia, N Bekas, E Kanata, A Chatziefsthathiou… - Redox Biology, 2024 - Elsevier
Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), are
protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are …
protein-based neurodegenerative disorders (NDs) affecting humans and animals. They are …
[HTML][HTML] The Underestimated Role of Iron in Frontotemporal Dementia: A Narrative Review
S Ferretti, I Zanella - International Journal of Molecular Sciences, 2024 - mdpi.com
The term frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders
characterized by the progressive degeneration of the frontal and temporal lobes of the brain …
characterized by the progressive degeneration of the frontal and temporal lobes of the brain …
Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots
ST Foliaki, CL Haigh - PLoS Pathogens, 2023 - journals.plos.org
AU: Pleaseconfirmthatallheadinglevelsarerepre…. Prion diseases are rare and incurable
neurodegenerative diseases caused by misfolding of prion protein (PrP) into abnormal …
neurodegenerative diseases caused by misfolding of prion protein (PrP) into abnormal …