Long terminal repeats: from parasitic elements to building blocks of the transcriptional regulatory repertoire

PJ Thompson, TS Macfarlan, MC Lorincz - Molecular cell, 2016 - cell.com
The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR)
retrotransposons, begins with transcription by RNA polymerase II followed by reverse …

Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis

GR Young, JP Stoye, G Kassiotis - Bioessays, 2013 - Wiley Online Library
A number of observations have led researchers to postulate that, despite being replication‐
defective, human endogenous retroviruses (HERVs) may have retained the potential to …

TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells

L Fasching, A Kapopoulou, R Sachdeva, R Petri… - Cell reports, 2015 - cell.com
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local
heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) …

[HTML][HTML] COVID-19 in children: expressions of type I/II/III interferons, TRIM28, SETDB1, and endogenous retroviruses in mild and severe cases

PA Tovo, S Garazzino, V Dapra, G Pruccoli… - International Journal of …, 2021 - mdpi.com
Children with the new coronavirus disease 2019 (COVID-19) have milder symptoms and a
better prognosis than adult patients. Several investigations assessed type I, II, and III …

Endogenous florendoviruses are major components of plant genomes and hallmarks of virus evolution

ADW Geering, F Maumus, D Copetti, N Choisne… - Nature …, 2014 - nature.com
The extent and importance of endogenous viral elements have been extensively described
in animals but are much less well understood in plants. Here we describe a new genus of …

Evolution of endogenous retroviruses in the subfamily of caprinae

AS Moawad, F Wang, Y Zheng, C Chen, AA Saleh… - Viruses, 2024 - mdpi.com
The interest in endogenous retroviruses (ERVs) has been fueled by their impact on the
evolution of the host genome. In this study, we used multiple pipelines to conduct a de novo …

[HTML][HTML] Enhanced transcription of human endogenous retroviruses and TRIM28 downregulation in patients with inflammatory bowel disease

PA Tovo, DG Ribaldone, I Galliano, GP Caviglia, M Dini… - Viruses, 2024 - mdpi.com
Inflammatory bowel disease (IBD) includes patients affected by Crohn's disease or
ulcerative colitis. IBD is thought to be a chronic immune-mediated disease, but its origin …

Identification and characterisation of endogenous Avian Leukosis Virus subgroup E (ALVE) insertions in chicken whole genome sequencing data

AS Mason, AR Lund, PM Hocking, JE Fulton, DW Burt - Mobile DNA, 2020 - Springer
Abstract Background Endogenous retroviruses (ERVs) are the remnants of retroviral
infections which can elicit prolonged genomic and immunological stress on their host …

Endogenous retroviruses transcriptional modulation after severe infection, trauma and burn

O Tabone, M Mommert, C Jourdan, E Cerrato… - Frontiers in …, 2019 - frontiersin.org
Although human endogenous retroviruses (HERVs) expression is a growing subject of
interest, no study focused before on specific endogenous retroviruses loci activation in …