Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease
The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ 42), total
Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau 181) have proven diagnostic …
Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau 181) have proven diagnostic …
Current state of Alzheimer's fluid biomarkers
JL Molinuevo, S Ayton, R Batrla, MM Bednar… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …
heterogeneous pathophysiology. The number of people living with AD is predicted to …
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the …
P Lewczuk, P Riederer, SE O'bryant… - The world journal of …, 2018 - Taylor & Francis
In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …
Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer's disease
MJ Leitão, A Silva-Spínola, I Santana, V Olmedo… - Alzheimer's Research & …, 2019 - Springer
Background Ongoing efforts within the Alzheimer's disease (AD) field have focused on
improving the intra-and inter-laboratory variability for cerebrospinal fluid (CSF) biomarkers …
improving the intra-and inter-laboratory variability for cerebrospinal fluid (CSF) biomarkers …
The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: a review
Introduction Cerebrospinal fluid (CSF) biomarkers have the potential to improve the
diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical …
diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical …
Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive …
I Baldeiras, I Santana, MJ Leitão, H Gens… - Alzheimer's research & …, 2018 - Springer
Background Cerebrospinal fluid (CSF) biomarkers have been used to increase the evidence
of underlying Alzheimer's disease (AD) pathology in mild cognitive impairment (MCI) …
of underlying Alzheimer's disease (AD) pathology in mild cognitive impairment (MCI) …
Derivation of cutoffs for the Elecsys® amyloid β (1–42) assay in Alzheimer's disease
LM Shaw, T Waligorska, L Fields… - Alzheimer's & …, 2018 - Wiley Online Library
Abstract Introduction An Elecsys® Amyloid β (Aβ [1–42]) immunoassay cutoff for
classification of patients with Alzheimer's disease was investigated. Methods Cerebrospinal …
classification of patients with Alzheimer's disease was investigated. Methods Cerebrospinal …
Proteomic approaches for the discovery of biofluid biomarkers of neurodegenerative dementias
Neurodegenerative dementias are highly complex disorders driven by vicious cycles of
intersecting pathophysiologies. While most can be definitively diagnosed by the presence of …
intersecting pathophysiologies. While most can be definitively diagnosed by the presence of …
Bridging the gap between fluid biomarkers for Alzheimer's disease, model systems, and patients
C Bjorkli, A Sandvig, I Sandvig - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by the
accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of …
accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of …
How to handle adsorption of cerebrospinal fluid amyloid β (1–42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ42 …
E Willemse, K van Uffelen, B Brix, S Engelborghs… - Alzheimer's & …, 2017 - Elsevier
Introduction We aimed to investigate factors defining amyloid β (1–42)(Aβ 1–42) adsorption
during preanalytical workup of cerebrospinal fluid (CSF). Methods CSF was transferred to …
during preanalytical workup of cerebrospinal fluid (CSF). Methods CSF was transferred to …