Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Pathways of amyloid-β aggregation depend on oligomer shape
One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
Transition metal ion interactions with disordered amyloid-β peptides in the pathogenesis of Alzheimer's disease: insights from computational chemistry studies
Monomers and oligomers of the amyloid-β peptide aggregate to form the fibrils found in the
brains of Alzheimer's disease patients. These monomers and oligomers are largely …
brains of Alzheimer's disease patients. These monomers and oligomers are largely …
Enhanced sampling and free energy calculations for protein simulations
Q Liao - Progress in molecular biology and translational …, 2020 - Elsevier
Molecular dynamics simulation is a powerful computational technique to study biomolecular
systems, which complements experiments by providing insights into the structural dynamics …
systems, which complements experiments by providing insights into the structural dynamics …
Aβ under stress: the effects of acidosis, Cu 2+-binding, and oxidation on amyloid β-peptide dimers
In light of the high affinity of Cu2+ for Alzheimer's Aβ1–42 and its ability to subsequently
catalyze the formation of radicals, we examine the effects of Cu2+ binding, Aβ oxidation, and …
catalyze the formation of radicals, we examine the effects of Cu2+ binding, Aβ oxidation, and …
Compact fibril-like structure of amyloid β-peptide (1–42) monomers
Amyloid β (Aβ) monomers are the smallest assembly units, and play an important role in
most of the individual processes involved in amyloid fibril formation. An important question is …
most of the individual processes involved in amyloid fibril formation. An important question is …
Edaravone inhibits the conformational transition of amyloid-β42: Insights from molecular dynamics simulations
Previous work has shown that edaravone inhibits fibrillogenesis of amyloid-β protein (Aβ).
However, the detailed mechanism by which edaravone inhibits the conformational transition …
However, the detailed mechanism by which edaravone inhibits the conformational transition …
Modular Protein Fibers with Outstanding High‐Strength and Acid‐Resistance Performance Mediated by Copper Ion Binding and Imine Networking
M Wang, Z Yang, B Jia, D Qin, Y Liu, F Wang… - Advanced …, 2024 - Wiley Online Library
Engineered protein fibers are promising biomaterials with diverse applications due to their
tunable protein structure and outstanding mechanical properties. However, it remains …
tunable protein structure and outstanding mechanical properties. However, it remains …