Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Engineered protein fibers are promising biomaterials with diverse applications due to their
tunable protein structure and outstanding mechanical properties. However, it remains …

One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Monomers and oligomers of the amyloid-β peptide aggregate to form the fibrils found in the
brains of Alzheimer's disease patients. These monomers and oligomers are largely …

Molecular dynamics simulation is a powerful computational technique to study biomolecular
systems, which complements experiments by providing insights into the structural dynamics …

In light of the high affinity of Cu2+ for Alzheimer's Aβ1–42 and its ability to subsequently
catalyze the formation of radicals, we examine the effects of Cu2+ binding, Aβ oxidation, and …

Previous work has shown that edaravone inhibits fibrillogenesis of amyloid-β protein (Aβ).
However, the detailed mechanism by which edaravone inhibits the conformational transition …

Amyloid-β (Aβ) and α-synuclein (αS) are two intrinsically disordered proteins (IDPs) at the
centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different …