The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer
membrane that plays a key role in host–pathogen interactions with the innate immune …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
http://thebiogrid. org) is an open access database that houses genetic and protein …

Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …

Efforts to map the Escherichia coli interactome have identified several hundred
macromolecular complexes, but direct binary protein-protein interactions (PPIs) have not …

The great recent progress made in identifying the molecular parts lists of organisms
revealed the paucity of our understanding of what most of the parts do. In this review, we …

Bacterial peptidoglycan (PG or murein) is a single, large, covalently cross‐linked
macromolecule and forms a mesh‐like sacculus that completely encases the cytoplasmic …

Bacterial cell envelope protein (CEP) complexes mediate a range of processes, including
membrane assembly, antibiotic resistance and metabolic coordination. However, only …

To date, cross-species comparisons of genetic interactomes have been restricted to small or
functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a …

The O-polysaccharide (O-PS; O-antigen) of bacterial lipopolysaccharides is made up of
repeating units of one or more sugar residues and displays remarkable structural diversity …