Local translation in neurons: visualization and function
Neurons are among the most compartmentalized and interactive of all cell types. Like all
cells, neurons use proteins as the main sensors and effectors. The modification of the …
cells, neurons use proteins as the main sensors and effectors. The modification of the …
Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
Massively parallel identification of mRNA localization elements in primary cortical neurons
S Mendonsa, N von Kügelgen, S Dantsuji, M Ron… - Nature …, 2023 - nature.com
Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …
cases due to the localization of many mRNAs to specific areas, where they are translated …
mRNA transport, translation, and decay in adult mammalian central nervous system axons
Localized mRNA translation regulates synapse function and axon maintenance, but how
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …
Context-specific regulation and function of mRNA alternative polyadenylation
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
Amyotrophic lateral sclerosis (ALS) is characterized by nucleocytoplasmic mislocalization of
the RNA-binding protein (RBP) TDP-43. However, emerging evidence suggests more …
the RNA-binding protein (RBP) TDP-43. However, emerging evidence suggests more …
Mechanistic insights into the basis of widespread RNA localization
M Chekulaeva - Nature Cell Biology, 2024 - nature.com
The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …
Design powerful predictor for mRNA subcellular location prediction in Homo sapiens
Messenger RNAs (mRNAs) shoulder special responsibilities that transmit genetic code from
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …
RNA-binding proteins balance brain function in health and disease
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …
decay provides an important regulatory layer in many if not all molecular pathways …