Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide
bound to a sialic acid-containing glycan chain, and locate at the plasma membrane …

Selection of the best tumor antigen is critical for the therapeutic success of chimeric antigen
receptor (CAR) T cells in hematologic malignancies and solid tumors. The anaplastic …

Abstract Purpose: Medulloblastoma (MB), the most common childhood malignant brain
tumor, has a poor prognosis in about 30% of patients. The current standard of care, which …

Purpose: Cytokine-engineering of chimeric antigen receptor-redirected T cells (CAR T cells)
is a promising principle to overcome the limited activity of canonical CAR T cells against …

Simple Summary Glycosylation is one of the most pivotal post-translational modifications on
all types of biomolecules for the formation of glycoproteins, glycolipids, and glycoRNAs in a …

Neuroblastoma has heterogenous clinical presentations that are reflected by several well-
defined clinical factors and biomarkers. Combinations of these clinical and biologic …

Cancers evolve not only through the acquisition and clonal transmission of somatic
mutations but also by epigenetic mechanisms that modify cell phenotype. Here, we use …

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Neuroblastoma is one of the commonest extra-cranial pediatric tumors, and accounts for
over 15% of all childhood cancer mortality. Risk stratification for children with neuroblastoma …