Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

[HTML][HTML] Effects of high fat diets on rodent liver bioenergetics and oxidative imbalance

PA Kakimoto, AJ Kowaltowski - Redox biology, 2016 - Elsevier
Human metabolic diseases can be mimicked in rodents by using dietary interventions such
as high fat diets (HFD). Nonalcoholic fatty liver disease (NAFLD) develops as a result of HFD …

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Z Kurt, R Barrere-Cain, J LaGuardia… - Biology of sex …, 2018 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and
more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver …

Long‐term measures of dyslipidemia, inflammation, and oxidative stress in rats fed a high‐fat/high‐fructose diet

C Feillet‐Coudray, G Fouret, C Vigor, B Bonafos… - Lipids, 2019 - Wiley Online Library
Inflammation and oxidative stress are thought to be involved in, or associated with, the
development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work …

Mitochondrial dysfunction in nonalcoholic steatohepatitis

G Serviddio, F Bellanti, G Vendemiale… - Expert review of …, 2011 - Taylor & Francis
The pathogenesis of nonalcoholic steatohepatitis (NASH) is poorly understood and the
mechanisms are still being elucidated. Mitochondrial dysfunction participates at different …

Diet-sensitive sources of reactive oxygen species in liver mitochondria: role of very long chain acyl-CoA dehydrogenases

AR Cardoso, PAHB Kakimoto, AJ Kowaltowski - PLoS One, 2013 - journals.plos.org
High fat diets and accompanying hepatic steatosis are highly prevalent conditions. Previous
work has shown that steatosis is accompanied by enhanced generation of reactive oxygen …

Exploiting common aspects of obesity and Alzheimer's disease

S Tabassum, A Misrani, L Yang - Frontiers in human neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an example of age-related dementia, and there are still no
known preventive or curative measures for this disease. Obesity and associated metabolic …

A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

I Grattagliano, CV Diogo… - World journal of …, 2013 - pmc.ncbi.nlm.nih.gov
AIM: To investigate the effectiveness of antioxidant compounds in modulating mitochondrial
oxidative alterations and lipids accumulation in fatty hepatocytes. METHODS: Silybin …

NF‐κB‐upregulated miR‐155‐5p promotes hepatocyte mitochondrial dysfunction to accelerate the development of nonalcoholic fatty liver disease through …

M Shen, H Pan, J Ke, F Zhao - Journal of Biochemical and …, 2022 - Wiley Online Library
Previous studies have highlighted the involvement of nuclear factor kappa B (NF‐κB) in the
development of nonalcoholic fatty liver disease (NAFLD). The purpose of our investigation is …

[HTML][HTML] Wilson disease: At the crossroads between genetics and epigenetics—A review of the evidence

DA Kieffer, V Medici - Liver research, 2017 - Elsevier
Environmental factors, including diet, exercise, stress, and toxins, profoundly impact disease
phenotypes. This review examines how Wilson disease (WD), an autosomal recessive …