Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms

T Vanzolini, M Bruschi, AC Rinaldi, M Magnani… - International Journal of …, 2022 - mdpi.com
Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …

Theranostics and artificial intelligence: new frontiers in personalized medicine

GB Bilgin, C Bilgin, BJ Burkett, JJ Orme… - …, 2024 - pmc.ncbi.nlm.nih.gov
The field of theranostics is rapidly advancing, driven by the goals of enhancing patient care.
Recent breakthroughs in artificial intelligence (AI) and its innovative theranostic applications …

Peptide-based drug delivery systems

D Berillo, A Yeskendir, Z Zharkinbekov, K Raziyeva… - Medicina, 2021 - mdpi.com
Peptide-based drug delivery systems have many advantages when compared to synthetic
systems in that they have better biocompatibility, biochemical and biophysical properties …

Peptides as pharmacological carriers to the brain: promises, shortcomings and challenges

S Parrasia, I Szabò, M Zoratti… - molecular …, 2022 - ACS Publications
Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Targeted nanomedicine: Lessons learned and future directions

N Veiga, Y Diesendruck, D Peer - Journal of Controlled Release, 2023 - Elsevier
Designing a therapeutic modality that will reach a certain organ, tissue, or cell type is crucial
for both the therapeutic efficiency and to limit off-target adverse effects. Nanoparticles …

[HTML][HTML] The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker

HA Holik, FM Ibrahim, AA Elaine, BD Putra, A Achmad… - Molecules, 2022 - mdpi.com
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …

[PDF][PDF] Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides

Y Fu, Y Xu, F Ruijne, OP Kuipers - FEMS Microbiology Reviews, 2023 - academic.oup.com
Natural bioactive peptide discovery is a challenging and time-consuming process. However,
advances in synthetic biology are providing promising new avenues in peptide engineering …

Non-canonical amino acids as building blocks for peptidomimetics: structure, function, and applications

TG Castro, M Melle-Franco, CEA Sousa… - Biomolecules, 2023 - mdpi.com
This review provides a fresh overview of non-canonical amino acids and their applications in
the design of peptidomimetics. Non-canonical amino acids appear widely distributed in …

[HTML][HTML] Recent applications of retro-inverso peptides

N Doti, M Mardirossian, A Sandomenico… - International Journal of …, 2021 - mdpi.com
Natural and de novo designed peptides are gaining an ever-growing interest as drugs
against several diseases. Their use is however limited by the intrinsic low bioavailability and …

Antimicrobial peptides as antimicrobials for wound care management: A comprehensive review

KA Kanaujia, N Mishra, PS Ra**ikanth… - Journal of Drug Delivery …, 2024 - Elsevier
Antimicrobial peptides (AMPs) are low-molecular-weight proteins having a presence in
almost all organisms, from prokaryotes to eukaryotes, and have been a fundamental part of …