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Targeting angiogenesis in oncology, ophthalmology and beyond
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …
Tumor angiogenesis: causes, consequences, challenges and opportunities
Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …
vary between tumor type and anatomic location, but also occur simultaneously within the …
VEGF signaling: role in angiogenesis and beyond
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …
Milestones in tumor vascularization and its therapeutic targeting
Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …
launched more than 50 years ago with the proposition and experimental demonstrations that …
Notch signaling in development, tissue homeostasis, and disease
Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …
Role of venous endothelial cells in developmental and pathologic angiogenesis
Background: Angiogenesis is a dynamic process that involves expansion of a preexisting
vascular network that can occur in a number of physiological and pathological settings …
vascular network that can occur in a number of physiological and pathological settings …
Mechanisms and regulation of endothelial VEGF receptor signalling
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …
required to balance the formation of new blood vessels with the maintenance and …
Vascular endothelial growth factor signaling in development and disease
Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …
orchestrating the development and maintenance of the blood and lymphatic vascular …
Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells
The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …
homeostasis, delivering essential molecules and blood cells, and removing waste products …
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation
Endothelial sprouting and proliferation are tightly coordinated processes mediating the
formation of new blood vessels during physiological and pathological angiogenesis …
formation of new blood vessels during physiological and pathological angiogenesis …