Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development

CR Ferraz, TT Carvalho, MF Manchope, NA Artero… - Molecules, 2020 - mdpi.com
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a
consequence of the pathological functioning of the nervous system rather than only a …

Naringenin nano-delivery systems and their therapeutic applications

M Bhia, M Motallebi, B Abadi, A Zarepour… - Pharmaceutics, 2021 - mdpi.com
Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and
is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa …

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

R Joshi, YA Kulkarni, S Wairkar - Life sciences, 2018 - Elsevier
Phenolic compounds constitute one of the important classes of secondary metabolites in the
plants. Flavonoids are primary phenolic compounds found in natural drugs. Naringenin is a …

Cyclodextrins as encapsulation agents for plant bioactive compounds

E Pinho, M Grootveld, G Soares, M Henriques - Carbohydrate polymers, 2014 - Elsevier
Plants possess a wide range of molecules capable of improve healing: fibre, vitamins,
phytosterols, and further sulphur-containing compounds, carotenoids, organic acid anions …

Analytical techniques for characterization of cyclodextrin complexes in the solid state: A review

P Mura - Journal of pharmaceutical and biomedical analysis, 2015 - Elsevier
Cyclodextrins are cyclic oligosaccharides able to form inclusion complexes with a variety of
hydrophobic guest molecules, positively modifying their physicochemical properties. A …

[HTML][HTML] Cyclodextrins as an encapsulation molecular strategy for volatile organic compounds—Pharmaceutical applications

AC Paiva-Santos, L Ferreira, D Peixoto, F Silva… - Colloids and Surfaces B …, 2022 - Elsevier
The use of essential oils has gained importance due to their wide range of biological
properties. Essential oils comprise a complex mixture of volatile organic compounds (VOCs) …

Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

P Ji, T Yu, Y Liu, J Jiang, J Xu, Y Zhao… - Drug design …, 2016 - Taylor & Francis
Naringenin (NRG), a flavonoid compound, had been reported to exhibit extensive
pharmacological effects, but its water solubility and oral bioavailability are only~ 46±6 µg/mL …

Encapsulation and delivery of bioactive citrus pomace polyphenols: A review

S Caballero, YO Li, DJ McClements… - Critical Reviews in …, 2022 - Taylor & Francis
Citrus pomace consists of the peel, pulp, and membrane tissues remaining after juice
expression. Globally, around one million tons of citrus pomace are generated annually …

[HTML][HTML] Flavonoids loaded in nanocarriers: an opportunity to increase oral bioavailability and bioefficacy

AR Bilia, B Isacchi, C Righeschi, C Guccione… - Food and Nutrition …, 2014 - scirp.org
Flavonoids are among the biggest group of polyphenols, widely distributed in plant-based
foods. A plethora of evidence supports the health benefits and value of flavonoids can play …

Therapeutic potential of naringin in neurological disorders

S Ahmed, H Khan, M Aschner, MM Hasan… - Food and Chemical …, 2019 - Elsevier
Neurological illnesses are multifactorial incurable debilitating disorders that may cause
neurodegeneration. These diseases influence approximately 30 million people around the …