Cells sense mechanical stress and changes in their matrix environment through the
integrins, a family of heterodimeric surface receptors that bind to extracellular matrix ligands …

Cardiovascular disease is the leading cause of death, medical complications, and
healthcare costs. Although recent advances have been in treating cardiovascular disorders …

The extracellular matrix (ECM) is the non-cellular component in the cardiac
microenvironment, and serves essential structural and regulatory roles in establishing and …

Muscular dystrophy exerts significant and dramatic impacts on affected patients, including
progressive muscle wasting leading to lung and heart failure, and results in severely …

Background Immune checkpoint blockade (ICB) has made remarkable achievements, but
newly identified armored and cold tumors cannot respond to ICB therapy. The high …

Renal fibrosis is a global health concern with limited curative treatment. Canonical transient
receptor potential channel 6 (TRPC6), a nonselective cation channel, has been shown to …

We previously found that the levels of metabolite N-acetylglutamine were significantly
increased in urine samples of patients with heart failure (HF) and in coronary artery ligation …

Liver metastasis depends on the collagenous microenvironment generated by hepatic
sinusoidal cells (SCs). DDR1 is an atypical collagen receptor linked to tumor progression …

Long non coding RNA growth arrest-specific transcript 5 (LncRNA GAS5) participate in the
formation of fibrosis diseases. However, the key role of LncRNA GAS5 in the development of …

Diabetic cardiomyopathy (DCM) is a common complication associated with diabetes. The
(pro) renin receptor (PRR) is an important member of the local tissue renin-angiotensin …