Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage,
HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs …

Fluid biomarkers for cognitive impairment have the advantage of being relatively
noninvasive and capable of monitoring neuronal and other brain cell health in real time …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …

Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

CD8+ T cell responses are critical for anti-tumor immunity. While extensively profiled in the
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …

Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …

Heatmap is a widely used statistical visualization method on matrix‐like data to reveal
similar patterns shared by subsets of rows and columns. In the R programming language …

Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells
persisting after curative intent therapy. The study of large patient cohorts incorporating …