Objectives To review clinical validation or implementation studies of maternal blood cell‐free
(cf) DNA analysis and define the performance of screening for fetal trisomies 21, 18 and 13 …

Cells release nanometer-scale, lipid bilayer-enclosed biomolecular packages (extracellular
vesicles; EVs) into their surrounding environment. EVs are hypothesized to be intercellular …

Plasma consists of DNA released from multiple tissues within the body. Using genome-wide
bisulfite sequencing of plasma DNA and deconvolution of the sequencing data with …

The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for
performing liquid biopsies for the assessment of solid tumors. Although its clinical potential …

Objective To review clinical validation or implementation studies of maternal blood cell‐free
(cf) DNA analysis and define the performance of screening for fetal trisomies 21, 18 and 13 …

Objective To measure test accuracy of non-invasive prenatal testing (NIPT) for Down,
Edwards and Patau syndromes using cell-free fetal DNA and identify factors affecting …

Massively parallel DNA-sequencing systems provide sequence of huge numbers of different
DNA strands at once. These technologies are revolutionizing our understanding in medical …

Objectives To report the clinical performance of massively parallel sequencing‐based non‐
invasive prenatal testing (NIPT) in detecting trisomies 21, 18 and 13 in over 140 000 clinical …

Purpose: Prenatal screening for Down syndrome has improved, but the number of resulting
invasive diagnostic procedures remains problematic. Measurement of circulating cell-free …

OBJECTIVE: To prospectively determine the diagnostic accuracy of massively parallel
sequencing to detect whole chromosome fetal aneuploidy from maternal plasma …