Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …

Tyrosinases are metalloenzymes belonging to the type‐3 copper protein family which
contain two copper ions in the active site. They are found in various prokaryotes as well as in …

The development of enzyme biosensors has successfully overcome various challenges
such as enzyme instability, loss of enzyme activity or long response time. In the …

The reactivities of tyrosinase and catechol oxidase have been of continued interest during
the last decades. To gain mechanistic insights into the conversion of mono-and diphenols by …

Enzymatic suicide inactivation, a route of permanent enzyme inhibition, is the mechanism of
action for a wide array of pharmaceuticals. Here, we developed the first nanosensor that …

Melanogenesis is responsible for skin pigmentation and the enzymatic browning of foods.
Tyrosinases play a major role in melanin synthesis, and many attempts have been made to …

The suicide inactivation mechanism of tyrosinase acting on its phenolic substrates has been
studied. Kinetic analysis of the proposed mechanism during the transition phase provides …

The human tyrosinase is the most prominent therapeutic target for pigmentary skin
disorders. However, the overwhelming majority efforts have been devoted to search …