The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

Hypertensive cardiac remodeling is characterized by left ventricular hypertrophy and
interstitial fibrosis, which can lead to heart failure with preserved ejection fraction. The Rho …

Objective—Rho/Rho-kinase (ROCK) pathway in vascular smooth muscle cells (VSMCs)
plays an important role in the pathogenesis of cardiovascular diseases, including pulmonary …

Current therapy of pulmonary arterial hypertension (PAH) is inadequate.
Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in …

Myocarditis refers to the clinical and histological characteristics of a diverse range of
inflammatory cellular pathophysiological conditions which result in cardiac dysfunction …

Background: Smooth muscle contraction is triggered primarily by activation of
Ca2+/calmodulin-dependent myosin light chain kinase leading to phosphorylation of the …

Ras homolog gene family member A (RhoA) belongs to the Rho GTPase superfamily, which
was first studied in cancers as one of the essential regulators controlling cellular function …