Biogenesis and regulatory roles of circular RNAs
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekee** noncoding RNAs and precursor …
as well as from the processing of cellular housekee** noncoding RNAs and precursor …
The expanding regulatory mechanisms and cellular functions of circular RNAs
LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …
The biogenesis, biology and characterization of circular RNAs
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However,
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that …
Best practice standards for circular RNA research
AF Nielsen, A Bindereif, I Bozzoni, M Hanan… - Nature …, 2022 - nature.com
Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as …
There has been an explosion in the number of circRNA papers in recent years; however, as …
The biogenesis, functions, and challenges of circular RNAs
Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …
of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low …
Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
Circular RNA (circRNA) is a class of covalently joined non-coding RNAs with functional roles
in a wide variety of cellular processes. Their composition shows extensive overlap with …
in a wide variety of cellular processes. Their composition shows extensive overlap with …
Functions and clinical significance of circular RNAs in glioma
J Sun, B Li, C Shu, Q Ma, J Wang - Molecular cancer, 2020 - Springer
CircRNAs are a class of single-stranded RNA molecules with a covalently closed loop
structure and have been characterized by high stability, abundance, conservation, and …
structure and have been characterized by high stability, abundance, conservation, and …
Drug screening at single-organoid resolution via bioprinting and interferometry
High throughput drug screening is an established approach to investigate tumor biology and
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …
Emerging functions of circular RNA in aging
Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes.
Recent studies indicate that the levels of circRNAs change with age in various tissues in …
Recent studies indicate that the levels of circRNAs change with age in various tissues in …