Tight junctions (TJs) are crucial for intercellular connections. The abnormal expression of
proteins related to TJs can result in TJ destruction, structural damage, and endothelial and …

This white paper examines the current challenges for treating ischemic stroke in diabetic
patients. The need for a greater understanding of the mechanisms that underlie the …

Introduction Ischemic stroke (IS) is a serious threat to human life and health, and cerebral
ischemia/reperfusion injury (CIRI) exacerbates IS by enhancing neuroinflammation and …

Early breach of the blood–brain barrier (BBB) and consequently extravasation of blood-
borne substances into the brain parenchyma is a common hallmark of ischemic stroke …

Tissue plasminogen activator (tPA) is the only FDA-approved treatment for ischemic stroke
but carries significant risks, including major hemorrhage. Additional options are needed …

Background Autophagy has been recently emerged as a prominent factor in the
pathogenesis of ischemic stroke (IS) and is increasingly being considered as a potential …

SHPL-49 is an innovative glycoside derivative that is synthesized by structural modifications
of salidroside, demonstrating therapeutic effects on animal models of ischemia in pre-clinical …

Introduction There is an urgent need for cerebroprotective interventions to improve the
suboptimal outcomes with intracerebral hemorrhage (ICH). Despite the important role of …

Abstract Background Neural stem cells (NSCs) play a crucial role in the progress of ischemic
stroke. Research on zebrafish embryonic demonstrates an association between Strawberry …

Stroke is a significant leading cause of death and disability in the United States (Tsao et al.,
2022). Approximately 87% of strokes fall into the ischemic category, mainly caused by …