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TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria
NM Dvorak, ND Domingo, CM Tapia… - Journal of …, 2023 - Springer
Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of
hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels …
hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels …
Inhibition of the Akt/PKB Kinase Increases Nav1.6-Mediated Currents and Neuronal Excitability in CA1 Hippocampal Pyramidal Neurons
In neurons, changes in Akt activity have been detected in response to the stimulation of
transmembrane receptors. However, the mechanisms that lead to changes in neuronal …
transmembrane receptors. However, the mechanisms that lead to changes in neuronal …
[HTML][HTML] Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons
LJ Steiger, T Tsintsadze, GB Mattheisen, SM Smith - Cell reports, 2023 - cell.com
Endogenous cannabinoid signaling is vital for important brain functions, and the same
pathways can be modified pharmacologically to treat pain, epilepsy, and posttraumatic …
pathways can be modified pharmacologically to treat pain, epilepsy, and posttraumatic …
Fibroblast growth factor 13-mediated regulation of medium spiny neuron excitability and cocaine self-administration
Cocaine use disorder (CUD) is a prevalent neuropsychiatric disorder with few existing
treatments. Thus, there is an unmet need for the identification of new pharmacological …
treatments. Thus, there is an unmet need for the identification of new pharmacological …
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons
Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential
as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 …
as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 …