Distance distributions between paramagnetic centers in the range of 1.8 to 6 nm in
membrane proteins and up to 10 nm in deuterated soluble proteins can be measured by the …

The biological function of protein, DNA, and RNA molecules often depends on relative
movements of domains with dimensions of a few nanometers. This length scale can be …

Parkinson's disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive
diseases that feature a common neuropathological hallmark of aggregated α-synuclein …

Distance distribution information obtained by pulsed dipolar EPR spectroscopy provides an
important contribution to many studies in structural biology. Increasingly, such information is …

Dipolar EPR spectroscopy (DEER and other techniques) enables the structural
characterization of macromolecular and biological systems by measurement of distance …

INTRODUCTION Transmembrane signaling of heterotrimeric guanine nucleotide–binding
protein (G protein)–coupled receptors (GPCRs) is mediated by ligand-dependent …

The established model-free methods for the processing of two-electron dipolar spectroscopy
data [DEER (double electron-electron resonance), PELDOR (pulsed electron double …

Pulsed electron-electron double resonance techniques such as the four-pulse double
electron-electron resonance experiment measure a dipolar evolution function of the sample …

α-Synuclein is known to play a causative role in Parkinson disease. Although its
physiological functions are not fully understood, α-synuclein has been shown to interact with …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …